Acceptable Daily Intake (ADI)

01/21/2026

“How does the WHO measure how much a certain substance in food or drinking water can be consumed daily over a lifetime without an appreciable health risk?”

NOAELs document how much of a substance an organism can handle before a statistically significant health effect occurs. However, these studies may be conducted in controlled environments or on test animals that may not accurately reflect human conditions. To account for all of these variables, organizations such as the World Health Organization (WHO) and the European Food Safety Authority (EFSA) use Acceptable Daily Intake (ADI). Acceptable daily intake measures the amount of a certain substance in food or drinking water that can be consumed daily over a lifetime without an appreciable health risk to people. This is commonly expressed as milligrams of substance per kilogram of body weight and is applied by regulatory and health authorities all over the world to monitor food additives, pesticides, and much more. Acceptable daily intake is applied to food ingredients similar to how reference dose is applied to environmental toxins.

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