Reference Dose (RfD)

01/20/26

“How does the U.S. EPA produce recommended daily lifetime exposure limits for substances?”

NOAELs are the highest level of a substance a person can take without any statistically significant effects, according to research. However, this could be much higher than what may actually be safe for long-term use. The U.S. EPA has created the Reference Dose (RfD) in response. Reference does are the maximum acceptable oral dose of a toxic substance that has no adverse noncancer health effects from a lifetime of exposure. Reference doses are commonly found by dividing the NOAEL for a substance by uncertainty factors.

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